Healing Rates:
Data from a multicenter, randomized, double-blind, parallel-group, 6-month
trial comparing NEXIUM 20 mg
with lansoprazole 15 mg administered once daily in patients with endoscopically
confirmed healed EE with
NEXIUM 40 mg.
†Log-rank test at 6 months.
Adapted from Lauritsen, et al.9
- NEXIUM 20 mg and lansoprazole 15 mg are the FDA-approved doses for maintenance of healing of EE
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which NEXIUM is an enantiomer5
The most frequently reported adverse events with NEXIUM
are headache, diarrhea, and abdominal pain. Symptomatic response to therapy
does not preclude the presence of gastric malignancy.
As with all PPIs,
patients treated concomitantly with warfarin may need to be monitored for
increases in INR and prothrombin time.
NEXIUM should be used only for the conditions, dosages, and durations specified in the
Prescribing Information. Before prescribing NEXIUM, please see accompanying
full Prescribing Information
