Dosing flexibility
Before prescribing NEXIUM, clarithromycin, or amoxicillin, please see important prescribing considerations below.
*The majority of patients are healed within 4-8 weeks. For patients who do not heal after 4-8 weeks, an additional 4-8 weeks of treatment may be considered.
†Controlled studies did not extend beyond 6 months.
‡If symptoms do not resolve completely after 4 weeks, an additional
4 weeks of treatment
may be considered.
The most frequently reported adverse events with NEXIUM are headache, diarrhea, and abdominal pain. Symptomatic response to therapy does not preclude the presence of gastric malignancy. As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time.
PRESCRIBING CONSIDERATIONS1
CLARITHROMYCIN PRESCRIBING CONSIDERATIONS
Because of the risk of potentially serious drug interactions, concomitant
administration of Clarithromycin with Pimozide is contraindicated.
Clarithromycin is contraindicated in patients with a known hypersensitivity
to any macrolide antibiotic. Clarithromycin may elevate digoxin serum concentrations. Patients should be carefully monitored while taking clarithromycin and digoxin concomitantly.
WARNING: CLARITHROMYCIN SHOULD NOT BE USED IN PREGNANT WOMEN EXCEPT
IN CLINICAL CIRCUMSTANCES WHERE NO ALTERNATIVE THERAPY IS APPROPRIATE.
IF PREGNANCY OCCURS WHILE TAKING CLARITHROMYCIN, THE PATIENT SHOULD BE
APPRISED OF THE POTENTIAL HAZARD TO THE FETUS. (See WARNINGS
in prescribing information for clarithromycin.)
AMOXICILLIN IS CONTRAINDICATED IN PATIENTS WITH A KNOWN HYPERSENSITIVITY
TO ANY PENICILLIN.
Eradication of H pylori reduces the risk of duodenal ulcer recurrence. In patients who fail therapy, susceptibility testing should be done. If
resistance to clarithromycin is demonstrated or susceptibility testing
is not possible, alternative antimicrobial therapy should be instituted.
NEXIUM is contraindicated in patients with known hypersensitivity to any
component of the formulation or to substituted benzimidazoles.
Consult complete prescribing information for clarithromycin and amoxicillin.
The most frequently reported adverse events with NEXIUM are headache, diarrhea, and abdominal pain. The most frequently reported drug-related adverse events for patients who received triple therapy for 10 days were diarrhea (9.2%), taste perversion (6.6%), and abdominal pain (3.7%).
NEXIUM should be used only for the conditions, dosages, and durations specified in the
Prescribing Information. Before prescribing NEXIUM, please see accompanying
full Prescribing Information
