References
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Support resources for your patients


Recommended patient support sites

AstraZeneca Sites:

NEXIUM Consumer Web Site
http://www.purplepill.com
The NEXIUM consumer Web site is a valuable patient resource and support vehicle. It offers patients information about their condition and about treatment with NEXIUM. Interactive tools help patients keep track of symptoms, monitor sleep habits, and plan GERD-friendly meals. Reminders help patients remember to take their NEXIUM as prescribed by their doctor.

Spanish-Language NEXIUM Consumer Web Site
http://www.pildoramorada.com
The Spanish-language NEXIUM consumer Web site offers patients information and answers to FAQs about their condition and about treatment with NEXIUM.

Other Sites:

Accent Health
http://www.accenthealth.com
Accent Health has an extensive consumer-oriented medical database. There is information on a variety of health and wellness topics, as well as articles, tips, interactive tools, and information on support groups. The site offers in-depth guides about chronic conditions as well as question-and-answer sessions with medical experts.

Centers for Disease Control and Prevention
http://www.cdc.gov
The site provides links to news, general information and traveler’s information, publications and software, and databases and statistics. Specific disease-oriented health information is available at http://www.cdc.gov/node.do/id/0900f3ec8000e035.

Dr. Koop
http://www.drkoop.com
This Web site offers health news, drug information, information about alternative medicine, message boards, information about specific conditions, and a medical encyclopedia.

Drug Digest
http://www.drugdigest.com
Drug Digest is a consumer information Web site sponsored by an independent pharmacy benefit company. The site has a wide variety of drug-related data, including information on specific drugs as well as drug classes, vitamins, herbs, drug interactions, and drug side effects. There is a section with a synopsis of information about treatment options.

Health A to Z
http://www.healthatoz.com
This is a patient-oriented site with information on a variety of diseases. The digestive disease library gives information on ulcers, a glossary of digestive disease terms, and suggestions for healthier eating habits.

InteliHealth
http://www.intelihealth.com
This site is sponsored by Aetna Healthcare and maintained by Johns Hopkins University. It contains a lot of general medical information geared to the consumer.

International Foundation for Gastrointestinal Disorders
http://iffgd.org
The purpose of the International Foundation for Gastrointestinal Disorders is “to inform, assist, and support people affected by functional gastrointestinal (GI) disorders.” The site provides access to research news, publications, and links to GERD-related information.

Mayo Clinic Health Oasis
http://www.mayohealth.org
This is the Mayo Clinic’s patient-oriented Web site. It has a daily news update, a chance to query Mayo Clinic experts, a library, special disease “centers,” a glossary, practical first aid advice, and interactive quizzes to test the patient’s health and nutritional knowledge. There is also a cookbook, a free e-mail bulletin, and links to other sites.

Medical University of South Carolina’s Digestive Disease Center
http://www.ddc.musc.edu
This site provides information about the Medical University of South Carolina’s Digestive Disease Center in general. The public information section offers consumer-friendly information specific to GI diseases.

MedicineNet
http://www.medicinenet.com
This site includes information on diseases, treatments, procedures, and tests; pharmacy information; information on first aid; and the numbers for poison control centers.

National Library of Medicine
http://www.nlm.nih.gov
From here, the user can access databases and NLM publications.

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
http://www.naspghan.org
This site offers disease information and educational tools, including an animated age-specific video designed to help parents and children better understand and manage symptoms of GERD.

Pediatric and Adolescent Gastroesophageal Reflux Association
http://reflux.org
This Web site offers information and support to parents and children dealing with GERD.

Additional Sites:

Yahoo!
http://health.yahoo.com/ency/healthwise/hw99177;_ylt=AkI0xPekIWACiHMwf6aIz13xurcF
Provides a GERD topic overview and access to related information.

MSN
http://health.msn.com/centers/heartburnandgerd/default.aspx
Offers news, message boards, and common questions relating to GERD and its treatment.

Mayo Clinic
http://www.mayoclinic.com/health/heartburn-gerd/DS00095
Provides a general overview of GERD, including signs and symptoms, risk factors, treatment, and self-care.

Univision
http://www.univision.com/content/channel.jhtml?chid=2&schid=125&secid=10881
Provides information for Spanish-speaking patients.

Terra (for Spanish-Speaking Patients)
http://www.terra.com/salud/especiales/acidez/
Provides information for Spanish-speaking patients.




Important Information

Approved Uses

Healing of EE
NEXIUM (esomeprazole magnesium) is indicated for the short-term treatment (4 to 8 weeks) in the healing and symptomatic resolution of diagnostically-confirmed erosive esophagitis.

For those patients who have not healed after 4-8 weeks of treatment, an additional 4-8 week course of NEXIUM may be considered.

Maintenance of EE Healing
NEXIUM is indicated for the maintenance of healing of erosive esophagitis. Controlled studies do not extend beyond 6 months.

Symptomatic GERD
NEXIUM is indicated for treatment of heartburn and other symptoms associated with GERD.

Pathological Hypersecretory Conditions
NEXIUM is indicated for the long-term treatment of pathological hypersecretory conditions. Dosage regimens should be adjusted to individual patient needs.

Risk Reduction of NSAID-Associated Gastric Ulcer
NEXIUM is indicated for the reduction in the occurrence of gastric ulcers associated with continuous NSAID therapy in patients at risk for developing gastric ulcers. Patients are considered at risk due to their age (≥60 years) and/or documented history of gastric ulcers. Controlled studies do not extend beyond 6 months.

Pediatric Use
NEXIUM is approved for the short-term treatment (up to 8 weeks) of GERD in patients aged 12 to 17 years. Safety and effectiveness for the treatment of symptomatic GERD in patients less than 12 years of age have not been established. Safety and effectiveness for other pediatric uses have not been established.

I.V. Indication
NEXIUM I.V. for Injection is indicated for the short-term treatment (up to 10 days) of GERD adult patients with a history of erosive esophagitis as an alternative to oral therapy in patients when therapy with NEXIUM Delayed-Release Capsules is not possible or appropriate.

When oral therapy is possible or appropriate, intravenous therapy with NEXIUM I.V. for Injection should be discontinued and the therapy should be continued orally.

 

Important Safety Information
NEXIUM and NEXIUM I.V. are contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles.

The most frequently reported adverse events with NEXIUM include headache, diarrhea, and abdominal pain. Injection site reactions have also been reported with NEXIUM I.V.

In patients aged 12 to 17 years, the most frequently reported adverse events with NEXIUM include headache, diarrhea, abdominal pain, and nausea.

Symptomatic response to therapy does not preclude the presence of gastric malignancy.

Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole, of which NEXIUM is an enantiomer.

As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts, and digoxin).

Concomitant administration of esomeprazole may reduce the plasma levels of atazanavir.

NEXIUM should be used only for the conditions, dosages, and durations specified in the Prescribing Information. Please see full Prescribing Information for NEXIUM.

 
 

NEXIUM and the color purple as applied to the capsule are registered trademarks and Purple Plus is a trademark of the AstraZeneca group of companies.
238402 5/07
Copyright © 2007 AstraZeneca LP. All rights reserved.

This product information is intended for US healthcare professionals only.
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© 2006 AstraZeneca
www.AstraZeneca.com